应用百合固金汤与利维爱对更年期综合征患者内分泌以及神经内分泌免疫网络的影响

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摘要 目的：探討应用百合固金汤以及利维爱对更年期综合征患者内分泌以及神经内分泌免疫网络的影响，为更年期综合征患者的临床治疗提供参考。方法：选取2014年3月至2017年5月青海省中医院收治的更年期综合征患者86例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组43例，其中对照组患者给予利维爱治疗，观察组在对照组治疗基础上加百合固金汤联合治疗，比较2组治疗前后的中医症状积分以及Kupperman积分，并分析2组治疗前后的血清生殖内分泌激素水平、神经递质以及免疫学指标的变化，观察2组的中医证候疗效情况。结果：治疗前，2组血清生殖内分泌激素水平、神经递质以及免疫学差异无统计学意义（P>0.05）。治疗后，2组中医症状积分、Kupperman积分、血清黄体生成素（LH）、卵泡刺激素（FSH）水平、5-羟色胺（5-HT）和去甲肾上腺素（NE）神经递质指标均明显降低，血清雌激素（E2）水平以及白细胞介素-2（IL-2）免疫学指标明显升高，而观察组上述指标改善更为显著，差异有统计学意义（P<0.05）。观察组的治疗有效率为95.35%，明显高于对照组，差异有统计学意义（P<0.05）。结论：百合固金汤联合利维爱治疗更年期综合征患者可以有效的调节神经内分泌免疫网络，提高雌激素的分泌，增强患者的免疫力，改善临床症状。

关键词 更年期综合征;百合固金汤;利维爱;内分泌;神经内分泌;免疫网络;中医证候;神经递质

Abstract Objective：To investigate the effects of Baihe Gujin Decoction and Livial on endocrine and neuroendocrine immune networks in menopausal syndrome patients， and provide reference for the clinical treatment of menopausal syndrome patients. Methods：A total of 86 patients with climacteric syndrome who were admitted to Qinghai Provincial Hospital of Traditional Chinese Medicine from March 2014 to May 2017 were randomly divided into the observation group and the control group， with 43 patients in each group. The control group was treated with Livial. The observation group was additionally treated with Baihe Gujin Decoction on the basis of the treatment of control group. The TCM （traditional Chinese medicine） symptom scores and Kupperman scores before and after treatment were compared between the two groups of patients. The changes of serum reproductive and endocrine hormone levels， neurotransmitters， and immune parameters before and after treatment were analyzed. The efficacy of TCM syndromes in the two groups was observed. Results：There was no significant difference in the levels of serum reproductive hormones， neurotransmitters， and immune parameters before treatment between the two groups （P>0.05）. The TCM symptom scores， Kupperman scores， serum LH and FSH levels， 5-HT and NE neurotransmitters were significantly decrease in the two groups after treatment， while Serum E2 levels and IL-2 immune parameters were significantly increased. And in the observation group， the above indicators improved more significantly （P<0.05）. The effective rate of treatment in the observation group was 95.35%， which was significantly higher than that in the control group. The difference was statistically significant （P<0.05）. Conclusion：The combination of Baihe Gujin Decoction with Livial in the treatment of patients with climacteric syndrome can effectively regulate the neuroendocrine immune network， improve the secretion of estrogen， enhance the patient′s immune system， and improve the clinical symptoms.